极速11选5

注射用苯磺顺阿曲库铵

发布时间:2012.08.26 来源:上海恒瑞 浏览次数:5966

极速11选5HEZHUNRIQI: 2006NIAN11YUE03RI

极速11选5XIUGAIRIQI: 2012NIAN03YUE14RI

XIUGAIRIQI: 2012NIAN10YUE01RI

XIUGAIRIQI: 2014NIAN07YUE13RI

XIUGAIRIQI: 2015NIAN03YUE09RI

XIUGAIRIQI: 2015NIAN12YUE01RI

注射用苯磺顺阿曲库铵说明书

请仔细阅读说明书并在医师指导下使用。

【药品名称】

TONGYONGMINGCHENG:ZHUSHEYONGBENHUANGSHUNAQUKUAN

YINGWENMINGCHENG:Cisatracurium Besilate for Injection

HANYUPINYIN:Zhusheyong Benhuangshun Aquku’an

【成份】

BENPINDEZHUYAOCHENGFENWEIBENHUANGSHUNAQUKUAN,QIHUAXUEMINGCHENGWEI:(1R,1’R,2R,2’R)-2,2’-(3,11-ERYANGDAI–4,10–ERYANGSHISANWANYAJIAJI)ER(1,2,3,4-SIQING-6,7-ERJIAYANG–2-JIAJI–1-LILUJIYIKUILIN)ERBENHUANGSUANYAN。

HUAXUEJIEGOUSHI:

分子式:C65H82N2O18S2

FENZILIANG:1243.49

极速11选5QIFULIAOWEIGANLUCHUNHEGOUYUANSUAN。

【性状】

BENPINWEIBAISEHUOLEIBAISESHUSONGKUAIZHUANGWUHUOFENMO。

【适应症】

BENPINYONGYUSHOUSHUHEQITACAOZUOYIJIZHONGZHENGJIANHUZHILIAO。ZUOWEIQUANMADE FUZHUYONGYAOHUOZAIZHONGZHENGJIANHUBINGFANG(ICU)QIZHENJINGZUOYONG,TAKEYISONGCHIGUGEJI,SHIQIGUANCHAGUANHEJIXIETONGQIYIYUJINXING。

【规格】

10mg(按C53H72N2O12计)

【用法用量】

SHIYONGQIANYONGMIEJUNZHUSHEYONGSHUI5mlRONGJIE。YUQITASHENJINGJIROUCHUANDAOZUZHIJIYIYANG,JIANYIZAISHIYONGBENPINGUOCHENGZHONGJIANCESHENJINGJIROUGONGNENGYIMANZUGETIHUAJILIANGDEYAOQIU。

静脉单次注射给药用法

成人剂量

极速11选5QIGUANCHAGUAN:BENPINYONGYUCHENGRENCHAGUANDETUIJIANJILIANGWEIMEIGONGJINTIZHONG0.15mgHUOZUNYIZHU。YONGBINGBOFENYOUDAOMAZUIHOU,ANCIJILIANGJIYUBENPIN,120MIAOHOUJIKEDADAOLIANGHAOZHIJIJIADECHAGUANTIAOJIAN。

极速11选5GAOJILIANGKEYISUODUANDUISHENJINGJIROUZUZHIZUOYONGDEQIXIAOSHIJIAN。

XIABIAOZONGJIELEAPIANLEI(LIUPENTUONA/FENTAINI/MIZUOANDING)HUOBINGBOFENMAZUIDEJIANKANGCHENGNIANBINGRENMEIGONGJINTIZHONGZHUSHE0.1~0.4mgBENPINHOUDEPINGJUNYAOXIAOXUESHUJU。

首次给药剂量(mg/kg)<?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />

麻醉背景

90%抑制的时间T1*()

达最大抑制的

时间T1*()

自然恢复至25%的时间T1*()

0.1

阿片类

3.4

4.8

45

0.15

丙泊酚

2.6

3.5

55

0.2

阿片类

2.4

2.9

65

0.4

阿片类

1.5

1.9

91

*:对尺神经进行超强的电刺激后,拇内收肌的单次颤搐反应或四个成串刺激的第一次颤搐反应。

YONGENFUWANHUOYIFUWANMAZUIKESHIBENPINSHOUJIDELINCHUANGYOUXIAOSHICHENGYANZHANGYUE15%。

WEICHIYONGYAO:CAIYONGWEICHIJILIANGYANZHANGBENPINSHENJINGJIROUDEZUZHIZUOYONG。DUIYIAPIANLEIHUOBINGBOFENMAZUIDEBINGREN,JIYU0.03mg/GONGJINTIZHONGDEBENPINKEYIJIXUCHANSHENGDAYUE20FENZHONGLINCHUANGYOUXIAODESHENJINGJIROUZUZHIZUOYONG。

极速11选5LIANXUSHIYONGWEICHIJILIANGBUHUIDAOZHISHENJINGJIROUZUZHIZUOYONGYANZHANG。

ZIRANHUIFU:SHENJINGJIROUZUZHIYIDANJINXINGZIRANHUIFU,QIHUIFUSUDUYUBENPINJIYAOLIANGWUGUAN。DANGSHIYONGAPIANLEIHUOBINGBOFENJINXINGMAZUISHI,CONG25%~75%JI5%~95%HUIFUDEPINGJUNSHIJIANFENBIEYUEWEI13HE30FENZHONG。

拮抗:给予标准剂量抗胆碱药物可以很容易地拮抗本品的神经肌肉阻滞作用。T1平均达10%恢复时给予拮抗剂,从25%到75%恢复及到临床完全恢复(T4/T1极速11选5≥0.7)的平均时间分别约为4分钟和9分钟。

2~12岁的儿童的给药剂量

2~12SUIERTONGDESHOUJISHUNBENHUANGSUANAQUKUANZHUSHEYEDETUIJIANJIYAOJILIANGWEI0.1mg/GONGJINTIZHONG,BINGZAI5~10MIAONEIJINXING。XIABIAOWEIAPIANLEIMAZUISHIPINGJUNYAOXIAOXUESHUJU。ZAIXIANGTONGDEMAZUIBEIJINGXIA,YI0.1mg/GONGJINTIZHONGDEJILIANGJIYAO,ERTONGBICHENGRENQIXIAOSHIJIANKUAI,LINCHUANGZUOYONGSHIJIANDUANQIEZIXINGHUIFUKUAI。

首次给药剂量mg/Kg(体重)

麻醉背景

90%抑制的时间(分钟)

到最大抑制的时间(分钟)

自然恢复至25%的时间(分钟)

0.1

阿片类

1.7

2.8

28

QIGUANCHAGUAN:SUIRANSHANGWUDUIGAINIANLINGZUJINXINGCHAGUANQIANJIYAODETEBIEYANJIUBAOGAO,DANJIANYUERTONGQIXIAOSHIJIANBICHENGRENKUAIZHEIYITEDIANKEYITUICE:JIYAOHOU2FENZHONGNEIJIKECHAGUAN。

极速11选5WEICHIYONGYAO:ZHUIJIASHIYONGBENPINKEYIWEICHIDUISHENJINGJIROUDEZUZHIZUOYONG。YIFUWANMAZUISHI,JIYU0.02mg/kg(TIZHONG)DEYAOLIANG,KEYIJIXUWEICHIYUE9FENZHONGLINCHUANGYOUXIAODESHENJINGJIROUZUZHI。LIANXUZHUIJIAJILIANGBUHUIYINQIXUJIXIAOYING。

极速11选5ZIRANHUIFU:YIAPIANLEIMAZUISHI,CONG25%DAO75%HUIFUHECONG5%DAO95%HUIFUSUOXUSHIJIANFENBIEYUEWEI10FENZHONGHE25FENZHONG。

拮抗:给予标准剂量抗胆碱药物可以很容易地逆转本品的神经肌肉阻滞作用。T1平均达13%恢复时给予拮抗剂,从25%到75%恢复的平均时间及到临床完全恢复(T4/T1≥0.7)的平均时间分别约为2分钟和5分钟。

静脉输注给药

成人和2~12岁儿童的用药剂量:

连续输注本品可以维持对神经肌肉的阻滞作用,在出现自然恢复迹象后要维持89%~99%的T1抑制,推荐首先以3g/kg/min(0.18mg/kg/hr)的速度输注,一旦达到稳定状态后,大部分病人只需要以1~2g/kg/min(0.06~0.12mg/kg/hr)的速度连续输注,即可维持阻滞作用。

DANGCAIYONGYIFUWANHUOENFUWANMAZUISHI,BENPINDESHUZHUSULVKEJIANSHAOGAODA40%。(JIANYAOWUXIANGHUZUOYONG)

SHUZHUSUDUQUJUEYUSHUZHURONGYEZHONGSHUNAQUKUANDENONGDU、SHENJINGJIROUZUZHISUOYAODADAODECHENGDUHEBINGRENDETIZHONG。XIABIAOSHIWEIXISHIDESHUNBENHUANGSUANAQUKUANZHUSHEYEDEJIYAOFANGFA。

2mg/mlDESHUNAQUKUANDESHUZHUSUDU:

病人体重(kg)

剂量(mg/kg/min)

输注速度

 

1.0

1.5

2.0

3.0

 

20

0.6

0.9

1.2

1.8

ml/hr

70

2.1

3.2

4.2

6.3

ml/hr

100

3.0

4.5

6.0

9.0

ml/hr

LIANXUHENGSUSHUZHUBENPINBINGBUHUIYINQIDUISHENJINGJIROUZUZHIXIAOYINGCHIXUDIJIAQIANGHUOJIANRUO。

TINGZHISHUZHUBENPINHOU,SHENJINGJIROUZUZHIDEZIRANHUIFUSUDUYUDANCIZHUSHEJIYAOHOUDEQINGKUANGLEISI。

2岁以下儿童的剂量

极速11选5MUQIANSHANGWU2SUIYIXIAERTONGYONGYAODEZILIAO,GUWUFATIGONGTUIJIANJILIANG。

老年患者的剂量:

NIANRENYONGYAOLIANGWUXUDIAOZHENG,QIYAOXIAODONGLIXUETEXINGYUNIANQINGDECHENGNIANBINGRENLEISI。DANYUQITASHENJINGJIROUZUZHIYAOWUYIYANG,YONGYULAONIANRENSHIQIXIAOKENENGSHAOMAN。

肾脏功能损害病人的剂量:

极速11选5SHENSHUAIBINGRENWUXUDIAOZHENGYONGYAOJILIANG。CILEIBINGRENBENPINDEYAOXIAODONGLIXUETEDIANYUSHENGONGNENGZHENGCHANGDEBINGRENLEISI,JINQIXIAOSHIJIANSHAOMAN。

肝脏功能损害病人的剂量:

WANQIGANBINGBINGRENWUXUDIAOZHENGYONGYAOJILIANG,CILEIBINGRENBENPINDEYAOXIAODONGLIXUETEDIANYUGANGONGNENGZHENGCHANGDEBINGRENLEISI,DANQIXIAOSHIJIANSHAOKUAI。

患心血管疾病病人的剂量:

曾对接受冠状动脉搭桥术(CABG)的严重心血管疾病成年患者(纽约心脏病协会I~III级)快速(5~10秒)静脉注射本品,在研究剂量下(£0.4mg/kg,8倍的ED95)未发现有临床意义的心血管作用。然而,在此病人群中,使用0.3mg/kg剂量以上的数据有限。

BENPINSHANGWEIYONGYUERTONGXINZANGSHOUSHUZHONG。

重症监护病房(ICU)病人的剂量:

KEJIANGBENPINTONGGUOJINGMAIZHUSHEHE/HUOJINGMAISHUZHUFANGSHIJIYUCHENGNIANICUBINGREN。

对成年ICU病人推荐的起始输注速度为3mg/kg/min(0.18mg/kg/hr)。但不同病人对药物的需求量有广泛的个体差异,并会随时间变化而增加或减少。临床研究中平均输注速度为3mg/kg/min【范围0.5~10.2mg/kg/min(0.03~0.6mg/kg/hr)】。

极速11选5ICUBINGRENZHANGQI(ZHANGDALIUTIAN)SHUZHUBENPINHOU,WANQUANZIRANHUIFUSUOXUDEPINGJUNSHIJIANYUEWEI50FENZHONG。

极速11选55mg/mlSHUNBENHUANGSUANAQUKUANZHUSHEYEDESHUZHUSULV

病人体重

剂量(mg/kg/min)

输注速度

kg

1.0

1.5

2.0

3.0

 

70

0.8

1.2

1.7

2.5

ml/hr

100

1.2

1.8

2.4

3.6

ml/hr

ICUBINGRENJIYUSHUNBENHUANGSUANAQUKUANZHUSHEYEHOUDEHUIFUQINGKUANGYUSHUZHUSHIJIANWUGUAN。

不相容性

极速11选5YIZHENGMINGBENPINZAIRUSUANLINGEZHUSHEYEJI5%PUTAOTANGHELINGEZHUSHEYEZHONGCHUXIANJIANGJIECHANWUDESUDUJIAOXIALIE‘SHIYONGZHINAN’XIANGSUOLIEDESHUZHUYEGENGKUAI。

YINCIBUTUIJIANRUSUANLINGEZHUSHEYEJI5%PUTAOTANGHELINGEZHUSHEYEZUOWEIBENPINDEXISHIYE。

极速11选5YINWEISHUNBENHUANGSUANAQUKUANZHUSHEYEZHIZAISUANXINGRONGYEZHONGWENDING,SUOYIBUNENGYUJIANXINGRONGYEGONGYONGZHUSHEQIHUOTONGSHIJIYAO(RULIUPENTUONA)。TAYUTONGGESUANANDINGSANCHUNHUOBINGBOFENZHUSHERUJIBUXIANGRONG。

使用指南

稀释后的顺苯磺酸阿曲库铵注射液应在聚氯乙烯或聚丙烯容器中存放。在5~25°C下,稀释后浓度为0.1~2mg/ml的顺苯磺酸阿曲库铵注射液于至少12小时内,其物理和化学性质稳定。稀释溶剂可以是下列溶液:氯化钠(0.9%w/v)静脉注射液;葡萄糖(5%w/v)静脉注射液;氯化钠(0.18%w/v)和葡萄糖(4%w/v)静脉注射液;氯化钠(0.45%w/v)和葡萄糖(2.5%w/v)静脉注射液。

SHUNBENHUANGSUANAQUKUANZHUSHEYEYUXIALIECHANGYONGDEWEISHUQIYAOWUJUYOUXIANGRONGXING,RU:YANSUANAFENTAINI、FUPAILIDUO、GOUYUANSUANFENTAINI、YANSUANMIDAZUOLUNHEGOUYUANSUANSHUFENTAINI,HEYONGSHIKETONGGUOSANTONGGUANJINXINGJINGMAISHUZHU。RUQITAYAOWUYUBENPINYONGTONGYIZHENGUANHUOTAOGUANJIYAO,JIANYIMEIZHUSHEYIZHONGYAOWUHOUYISHILIANGDEJINGMAISHUZHUYE(RU0.9%w/vLVHUANAJINGMAISHUZHUYE)JIANGYAOWUCHONGJIN。

YUQITAJINGMAIYONGYAOLEISI,RUXUANZEZAIXIAOJINGMAIZHUSHEBENPINSHI,ZHUSHEHOU,XUYISHILIANGDEJINGMAISHUYE(RU0.9%w/vDELVHUANAJINGMAIZHUSHEYE)JIANGSHUNBENHUANGSUANAQUKUANZHUSHEYECHONGJINGAIJINGMAI。

【不良反应】

YIJILUDESHIYONGBENPINDEBULIANGFANYINGYOUPIFUCHAOHONGHUOPIZHEN、XINDONGGUOHUAN、DIXUEYAHEZHIQIGUANJINGLUAN。

SHIYONGSHENJINGJIROUZUZHIJIHOUKEGUANCHADAOBUTONGCHENGDUDEGUOMINFANYING。JISHAOSHUQINGKUANGXIA,DANGBENPINYUYIZHONGHUODUOZHONGMAZUIYAOHEYONGSHI,YOUYANZHONGGUOMINFANYINGDEBAODAO。

YOUBAODAOZAIZHONGZHENGJIANHUBINGFANGDEYANZHONGJIHUANBINGRENZAIGUOZHANGSHIJIANSHIYONGJIROUSONGCHIJIHOUCHUXIANJIWULIHE/HUOJIBING。DABUFENBINGRENTONGSHIJIESHOULEIGUCHUNZHIJI,SHANGSHUQINGKUANGZAISHIYONGBENPINHOUOUYOUBAOGAO,DANQIYINGUOGUANXISHANGWEIQUEDING。

【禁忌】

YIZHIDUISHUNAQUKUAN、AQUKUANHUOBENHUANGSUANGUOMINJIDUIBENPINZHONGRENHECHENGFENGUOMINZHEJINZHISHIYONG。

【注意事项】

SHUNSHIBENHUANGSUANSHUNAQUKUANNENGSHIHUXIJIHEQITAGUGEJITANHUAN,ERDUIYISHIHETONGYUMEIYOUYINGXIANG。SHUNBENHUANGSUANAQUKUANZHUSHEYEYINGJINYOUMAZUISHIHUOZAIMAZUISHIJIQITASHUXISHENJINGJIROUZUZHIJISHIYONGDEYISHENGZHIDAOXIAJIYAO。TONGSHIBIXUBEIYOUWANSHANDEQIGUANCHAGUAN、RENGONGHUXISHEBEIYIJICHONGZUDEYANGQIGONGYING。

DUIYUQITASHENJINGJIROUZUZHIJIGUOMINDEBINGRENZAISHIYONGBENPINSHIYINGYINQIGAODUZHONGSHI,YINWEIYOUBAODAOCUNZAISHENJINGJIROUZUZHIJIDEJIAOCHAFANYING。

极速11选5SHUNAQUKUANWUMINGXIANDEMIZOUSHENJINGYIZHIZUOYONGHUOSHENJINGJIEZUZHIZUOYONG。GULINCHUANGSHANGDUIXINLVMEIYOUMINGXIANDEYINGXIANG,YIBUNENGJIEKANGYOUDUOZHONGMAZUIYAOHUOSHUZHONGYINCIJIMIZOUSHENJINGERYINQIDEXINDONGGUOHUAN。

极速11选5ZHONGZHENGJIWULIJIQITAXINGSHIDESHENJINGJIROUJIBINGHUANZHEDUIFEIQUJIHUAZUZHIJIDEMINGANXINGXIANZHUZENGGAO。ZHEIXIEBINGRENSHIYONGBENPINDETUIJIANQISHIJILIANGWEIBUDAYU0.02mg/kg。

YANZHONGDESUANJIANSHIDIAOHE/HUOXUEJIANGZHONGDIANJIEZHIWENLUANKEZENGJIAHUOJIANGDIDUISHENJINGJIROUZUZHIJIDEMINGANXING。

极速11选5SHANGWUYUNFUYINGYONGBENPINDEZILIAO,YINWEIWEIDUICILEIRENQUNJINXINGYANJIU(JIANYUNFUJIBURUQIFUNVYONGYAO)。

极速11选5SHANGWU2SUIYIXIAERTONGYINGYONGBENPINDEZILIAO,YINWEISHANGWEIDUICILEIRENQUNJINXINGYANJIU。

极速11选5SHANGWUDUIHUANYOUEXINGGAORESHIDEBINGRENSHIYONGBENPINDEYANJIUBAOGAO。DUIYIGANDONGWU(ZHU)DEEXINGGAOREZHENGDEYANJIUBIAOMING,SHUNAQUKUANBINGBUHUIYOUFACIZHENG。

尚无低体温(25~28°C)条件下手术病人使用本品的研究报告。与其它神经肌肉阻滞药物相类似,在这种情况下维持手术要求的肌肉松弛程度所需的输注速率应明显减低。

极速11选5SHANGWUSHAOSHANGBINGRENSHIYONGBENPINDEYANJIUBAOGAO,DANYINGYUQITAFEIQUJIHUASHENJINGJIROUZUZHIYAOWULEISI。DANGCILEIBINGRENJIYUSHUNBENHUANGSUANAQUKUANZHUSHEYESHI,YINGKAOLVSUOXUJILIANGKENENGZENGJIAERZUOYONGSHIJIANSUODUAN。

ZHONGZHENGJIANHUBINGFANG(ICU)HUANZHEJIYUSHIYANDONGWUGAOJILIANGBENPINHOU,BENPINDEDAIXIECHANWU-LAODANJIANHEAQUKUANKENENGYUZANSHIXINGDIXUEYAYOUGUAN。MOUXIEZHONGSHUCHUXIANNAOXINGFEN。ZAIZUIMINGANDEDONGWUZHONG,CHUXIANSHANGSHUFANYINGSHIDEXUEJIANGLAODANJIANDEXUEYAONONGDUYUZHANGSHIJIANSHUZHUAQUKUANGUANCHADEBUFENICUHUANZHEDEXIANGYINGNONGDUXIANGLEISI。

极速11选5YUJIANGDIBENPINSHUZHUSUDUDEJIEGUOXIANGYIZHI,SHUZHUAQUKUANHOU,XUEJIANGLAODANJIANNONGDUYUEWEI1/3。

HANJIANBAODAOSHIYONGAQUKUANHUOQITAYAOWUDEICUHUANZHEFASHENGDIANXIAN。ZHEIXIEHUANZHETONGCHANGCUNZAIYIZHONGHUODUOZHONGRONGYIDAOZHIDIANXIANDEYOUYIN(RUNAOWAISHANG、NAOQUEYANG、NAOSHUIZHONG、BINGDUXINGNAOYAN、NIAODUZHENG)。SHANGSHUFANYINGYULAODANJIANDEYINGUOGUANXISHANGWEIQUEDING。

极速11选5DUIJIACHEHESHIYONGJIQINENGLIDEYINGXIANG

极速11选5CIZHUYISHIXIANGTONGBENPINSHIYONGWUGUAN,DANQUANSHENMAZUIYAOSHIYONGDEZHUYISHIXIANGYISHIYONGYUBENPIN。

【孕妇及哺乳期妇女用药】

BENPINJINYONGYUYUNFU,YINWEISHANGWEIDUICILEIRENQUNJINXINGYANJIU。SHENGYULIYANJIUSHANGWEIJINXING。DASHUDESHENGZHIDUXINGYANJIUWEIJIANBENPINDUITAIZIDEBULIANGFANYING,YOUYUZHONGSHUDAIXIECHAYIJIDIXITONGBAOLUSHUIPING,ZHEIXIEYANJIUDESHIYONGXINGSHIYOUJUXIANDE。

极速11选5BENPINJIDAIXIECHANWUSHIFOUFENMIDAORENRUSHANGBUKEZHI。

【儿童用药】

SHANGWU2SUIYIXIAERTONGYINGYONGBENPINDEZILIAO,YINWEISHANGWEIDUICILEIRENQUNJINXINGYANJIU。2SUIYISHANGERTONGYONGYAOXIANGJIAN【YONGFAYONGLIANG】XIANGXIA。

【老年用药】

LAONIANRENYONGYAOLIANGWUXUDIAOZHENGHUOZUNYIZHU,QIYAOXIAODONGLIXUETEXINGYUNIANQINGDECHENGNIANBINGRENLEISI。DANYUQITASHENJINGJIROUZUZHIYAOWUYIYANG,YONGYULAONIANRENSHIQIXIAOSHAOMAN。

【药物相互作用】

HENDUOYAOWUDOUNENGYINGXIANGFEIQUJIHUASHENJINGJIROUZUZHIYAOWUDEQIANGDUHEZUOYONGSHIJIAN,QIZHONGBAOKUO:

增强疗效的药物:

MAZUIJI:RUENFUWAN、YIFUWANHEFUWAN(JIANYONGFAYONGLIANG)、LVANTONG、QITAFEIQUJIHUASHENJINGJIROUZUZHIYAO。

QITAYAO:

KANGSHENGSU:BAOKUOANJITANGGANLEI、DUOZHANJUNSU、DAGUANMEISU、SIHUANSU、LINKEMEISUHEKELINMEISU。

KANGXINLVBUQIYAOWU:BAOKUOXINDEAN、GAITONGDAOZUZHIJI、LIDUOKAYIN、PULUKAYINXIANANHEKUINIDING。

LINIAOJI:BAOKUOFUSAIMI,KENENGHAIBAOKUOSAIQINLEI、GANLUCHUNHEYIXIANZUOAN。

MEIYAN。

LIYAN。

极速11选5SHENJINGJIEZUZHIJI:SANJIASAIFANG、LIUJIAAN。

降低疗效的药物:

DUIYUCENGZHANGQISHIYONGBENTUOYINGHEKAMAXIPINGDEHUANZHE,SHIYONGBENPINLIAOXIAOKENENGJIANGDI。

极速11选5SHIXIANJIYUHUPOXIANDANJIANBUHUIYINGXIANGJINGZHUHUOJINGSHUBENPINHOUDESHENJINGJIROUZUZHIZUOYONGSHIJIAN,WUXUGAIBIANDANCIJIYAOJILIANGHUOSHUZHUJIYAOSUDU。

HEYONGHUPOXIANDANJIANLAIYANZHANGFEIQUJIHUASHENJINGJIROUZUZHIJIDEXIAOYINGKENENGDAOZHIYANZHANGDEFUHEXINGZUZHIZUOYONGERNANYIYONGKANGDANJIANZHIMEIYAONIZHUAN。

罕见有某些药物可加剧或诱发隐性重症肌无力发作,或实际上是诱发一种肌无力综合征;在此情况下,病人对非去极化神经肌肉阻滞剂的敏感性可能增加。这些药物包括各种抗生素、b-受体阻滞剂(心得安、心得平)、抗心律不齐药(普鲁卡因酰胺、奎尼丁)、抗风湿药(氯喹、D-青霉胺)、三甲噻方、氯丙嗪,类固醇、苯妥英和锂剂。

【药物过量】

症状和体征:

BENPINGUOLIANGDEZHUYAOBIAOXIANWEIJIROUMABISHIJIANYANZHANGJIXIANGGUANHOUGUO。

处理方法

极速11选5ZUIZHUYAODESHIWEICHIFEIBUTONGQIHEDONGMAIGONGYANG,ZHIDAOHUIFUZUGOUDEZIZHUHUXI。SHUNBENHUANGSUANAQUKUANZHUSHEYEBINGBUYINGXIANGYISHI,YINCI,CISHIXUYAOCHONGFENZHENJING。YIDANCHUXIANZISHENHUIFUDEJIXIANG,JIYUKANGDANJIANZHIMEIYAOJIANGJIASUJIROUSONGCHIDEHUIFU。

【药理毒理】

药理作用

SHUNBENHUANGSUANAQUKUANSHIYISHENJINGJIROUZUZHIJI。

极速11选5SHUNBENHUANGSUANAQUKUANSHIZHONGXIAODE、FEIQUJIHUADE、JUYIKUILINWENGBIANZHIJIEGOUDEGUGEJISONGCHIJI。

极速11选5RENTILINCHUANGYANJIUBIAOMING,BENPINYUJILIANGYILAIDEZUANSHIFANGWUGUAN,SHENZHIZAIJILIANGGAODAED95DE8BEISHIYISHIRUCI。

SHUNBENHUANGSUANAQUKUANZAIYUNDONGZHONGBANSHANGYUDANJIANNENGSHOUTIJIEHE,YIJIEKANGYIXIANDANJIANDEZUOYONG,CONGERCHANSHENGJINGZHENGXINGDESHENJINGJIROUCHUANDAOZUZHIZUOYONG。ZHEIZHONGZUOYONGHENRONGYIBEIKANGDANJIANMEIYAOWURUXINSIDEMINGHUOTENGXILONGJIEKANG。

DANGYIAPIANLEIYAOWUMAZUISHI(LIUPENTUONA/FENTAINI/MIDAZUOLUN),SHUNAQUKUANDEED95(CIJICHISHENJINGYINQIDEMUNEISHOUJIZHANCHUFANYINGSHOUDAO95%YIZHISUOXUDEYAOLIANG)DAYUEWEI0.05mg/kgTIZHONG。

极速11选5YIFUWANMAZUISHI,ERTONGSHUNAQUKUANDEED95WEI0.04mg/kgTIZHONG。

毒理作用

急性毒性:阿曲库铵的有意义的急性毒性研究无法进行。 毒性反应见‘药物过量’章节。

亚急性毒性极速11选5:狗和猴为期三周的重复给药研究表明没有化合物特异性中毒征象。

致突变性:当顺阿曲库铵浓度达5000g/板时,体外微生物致突变试验未表明有致突变作用。大鼠的体内细胞遗传试验中,皮下注射剂量为4mg/kg体重时,未观察到明显的染色体异常。当顺阿曲库铵的浓度为40mg/ml或更高时,小鼠的体外淋巴细胞致突变试验表明有致突变性。很少和/或短暂使用药物出现的个别致突变阳性结果,其临床相关性尚有疑问。

致癌性:致癌研究尚未进行。

局部耐受性:对家兔进行的一项动脉内研究结果表明,本品耐受性良好,且未观察到与药物有关的变化。

【药代动力学】

SHUNAQUKUANZHUYAOSHITONGGUOZAISHENGLIpHZHIJITIWENXIAFASHENGDEHofmannQINGCHU(HUAXUEGUOCHENG)ERJIANGJIEWEILAODANSUHEDANJIANYANBINGXISUANYANDAIXIEWU,HOUZHETONGGUOFEITEYIXINGMEISHUIJIEERXINGCHENGDANJIANYANYICHUNDAIXIEWU。SHUNAQUKUANDEQINGCHUJUYOUJIAOQIANGDEQIGUANYILAIXING。GANHESHENWEIDAIXIEWUDEZHUYAOQINGCHUTUJING。ZHEIXIEDAIXIEWUBUJUYOUSHENJINGJIROUCHUANDAOZUZHIZUOYONG。

成年患者的药代动力学

ZAI0.1~0.2mg/kgJILIANGFANWEINEI(JI2~4BEIDEED95)DEYANJIUBIAOMING,SHUNAQUKUANFEIFANGSHIYAODAIDONGLIXUEYUJILIANGWUGUAN。

群体药代动力学证实上述现象并将剂量延伸至0.4mg/kg(ED95极速11选5的8倍)。健康成年手术患者给予本品0.1~0.2mg/kg的药代动力学参数如下:

参数

平均值范围

清除率

4.75.7mL/min/kg

稳态分布容积

121161mL/kg

清除半衰期

2229min

老年患者的药代动力学

极速11选5WEIJIANLAONIANHEQINGNIANHUANZHEYAODAIDONGLIXUEJUYOULINCHUANGYIYIDECHABIE。QIHUIFUQINGKUANGYIWUMINGXIANBIANHUA。

肝肾损害患者的药代动力学

极速11选5WEIJIANSHENSHUAIWANQIHEGANZANGJIBINGWANQIHUANZHEDEYAODAIDONGLIXUEYUCHENGRENHUANZHE(WUGANSHENJIHUAN)YOUMINGXIANCHABIE。QIHUIFUQINGKUANGYIWUMINGXIANBIANHUA。

输注过程中的药代动力学

JINGMAISHUZHUSHUNAQUKUANYUDANCIZHUSHEJIYAODEYAODAIDONGLIXUEXIANGSI。BENPINDEHUIFUQINGKUANGBUYILAIYUSHUZHUSHIJIAN,YIYUDANCIZHUSHEJIYAOXIANGSI。

重症监护病房(ICU)患者的药代动力学

YANZHANGSHUZHUSHIJIANDEICUHUANZHE,SHUNAQUKUANDEYAODAIDONGLIXUEYUSHUZHUHUODANCIZHUSHEJIYAODEJIANKANGZHELEISHOUSHUCHENGNIANHUANZHELEISI。CILEIHUANZHEDEHUIFUQINGKUANGBUYILAIYUSHUZHUSHIJIAN。

极速11选5GAN/SHENGONGNENGYICHANGDEICUHUANZHEDEDAIXIEWUNONGDUJIAOGAO(JIANZHUYISHIXIANG)。CIDAIXIEWUWUSHENJINGJIROUCHUANDAOZUZHIZUOYONG。

【贮藏】

ZHEGUANG,MIBI,YU2~8℃BAOCUN。

【包装】

XILINPING,10PING/HE。

【有效期】

18GEYUE。

【执行标准】

极速11选5《ZHONGGUOYAODIAN》2015NIANBANDIERBUJI YBH02672014

【批准文号】

GUOYAOZHUNZIH20061298

【生产企业】

委托方企业名称:极速11选5 江苏恒瑞医药股份有限公司

极速11选5    SHENGCHANDIZHI:LIANYUNGANGJINGJIJISHUKAIFAQULINGANGCHANYEQUDONGJINLU

极速11选5    ZHUCEDIZHI:LIANYUNGANGJINGJIJISHUKAIFAQUHUANGHELU38HAO

    YOUZHENGBIANMA:222000

    DIANHUAHAOMA:800-8283900 400-8283900

    CHUANZHENHAOMA:0518-85463261

    WANG ZHI:http://www.hrs.com.cn

受托方企业名称: 上海恒瑞医药有限公司

    SHENGCHANDIZHI:SHANGHAISHIMINXINGQUJINGJIJISHUKAIFAQUWENJINGLU279HAO

    ZHUCEDIZHI:SHANGHAISHIMINXINGQUJINGJIJISHUKAIFAQUWENJINGLU279HAO

    YOUZHENGBIANMA:200245

极速11选5    DIANHUAHAOMA:021-54759103

极速11选5    WANG ZHI:http://blumblum.com



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