极速11选5

盐酸氮卓斯汀鼻喷雾剂

发布时间:2012.08.26 来源:上海恒瑞 浏览次数:5508

极速11选5HEZHUNRIQI:2007NIAN01YUE31RI

极速11选5XIUGAIRIQI:2014NIAN10YUE04RI

XIUGAIRIQI:2015NIAN12YUE01RI

盐酸氮卓斯汀鼻喷雾剂说明书

请仔细阅读说明书并在医师指导下使用。

【药品名称】

TONGYONGMINGCHENG:YANSUANDANZHUOSITINGBIPENWUJI

SHANGPINMINGCHENG:FUDI

YINGWENMINGCHENG:Azelastine Hydrochloride Nasal Spray

HANYUPINYIN:Yansuan Danzhuositing Bipenwuji

【成份】

BENPINZHUYAOCHENGFENWEIYANSUANDANZHUOSITING。

极速11选5HUAXUEMINGCHENG:4-(4-LVBENJIAJI)-2-(LIUQING-1-JIAJI-1H-DANZHUOJI-4-JI)-1(2H)-2,3-ERDANZANAITONGYANSUANYAN。

HUAXUEJIEGOUSHI:

分子式:C22H24ClN3O·HCl

FENZILIANG:418.37

【性状】

极速11选5BENPINYINGWEIWUSECHENGMINGYETI,QINYAFAMEN,YAOYEJICHENGWUZHUANGDINGLIANGPENCHU。

【适应症】

YONGYUZHILIAOJIJIEXINGGUOMINXINGBIYANHEFEIJIJIEXINGGUOMINXINGBIYAN。

【规格】

10ml :10mg,70PEN,MEIPEN0.14 mg。

【用法用量】

JIANYIYONGLIANG:MEITIAN2CI(ZAOSHANGHEWANSHANG),MEICISHIYONGSHI,MEIYIBIKONGGEPENYICI(XIANGDANGYUMEITIAN0.56 mgYANSUANDANZHUOSITING)。LIANXUSHIYONGZHIZHENGZHUANGXIAOSHI,SHIYONGSHIJIANBUYAOCHAOGUOLIANXU6GEYUE。

极速11选5SHIYONGFANGFA:YANSUANDANZHUOSITINGBIPENWUJIJINYONGYUBIQIANGPENRU。BINGXIANGJIANSHIYONGTUJIESHUOMING。

极速11选5YANSUANDANZHUOSITINGBIPENWUJISHIYONGTUJIESHUOMING:

1.BOKAIGAIZI(TU1),(RUGUOHUODONGPENTOUTUOLUO,YINGZHONGXINZHUANGRU),YAODONGYAOPING。

2.ZAIDIYICISHIYONGQIANXUDIAOZHENGPENTOUDAOZUIJIAZHUANGTAI。JIANGLIANGGEZHITOUFANGZAIPINGZIDE“LIANGJIAN”,MUZHIFANGZAIPINGDI,YONGLIANYAFAMEN(TU2)ZHIZHICHUXIANLIANGHAODEPENWUZHUANGTAI(YIBANAN5CI),BIAOMINGPENTOUYIJINGDIAOZHENGZHIZUIJIAZHUANGTAI,KEYISHIYONG。QIEJIJIANGPENTOUDIAOZHENGZHIZUIJIAZHUANGTAIZAISHIYONG,ZHEIYANGNENGQUEBAOJIYAOJILIANGZHUNQUE。

极速11选53.QINGJIEBIKONG,SHIBIKONGTONGCHANG。JIANGPENTOUSHENRUBIKONG(YUE1cm),TOUXIANGQIANQING(TU3),WUZHUANGYAOWUKEZHIDABIHOUBU。ZHUNBEIWANBIHOUYONGZHITOUANZHULINGYIGEBIKONG(TU4),HELONGZUIBUBIZIQINGQINGXIQIDETONGSHI,QIANGERKUAIDIQINYAFAMEN,PENRUGUIDINGLIANGDEYAOWU,PENWUJIESHUHOU,CONGBIBUYIKAIPENBIQI,YANGTOU,QINGQINGXIQISHUMIAOZHONG。RUOXUZENGJIAJILIANGHUANLINGYIBIKONGZHONGFUSHANGSHUBUZHOU,YONGYAOHOU15FENZHONGNEI,BUYAOXINGBITI。

4.YONGBIHOU,GAISHANGGAIZI。

【不良反应】

GENJUGUOWAIWENXIANBAODAO,ZAIJIQIXISHAODEQINGKUANGXIA,HUIYOUYUPENRUPENJIERDAOZHIDUIYIFAYANDEBIQIANGNIANMODECIJI。ZHEIZHONGXIANXIANGKEYIMIAOSHUWEIZHUOTONG,SAOYANGHEDAPENTI。

ZAISHAOSHUQINGKUANGXIAYOUKENENGDAOZHICHUBIXUE。

极速11选5ZAIBUQIADANGDESHIYONGXIA(TOUBUXIANGHOUQINGXIE,CANJIANPEIYAOZHINAN),KENENGYOUKUWEIJINRUKOUQIANG,YOUSHIKENENGDAOZHIEXINHEOUTU。

JIJIEXINGDEGUOMINXINGBIYAN:

YANSUANDANZHUOSITINGBIPENWUJIDEBULIANGFANYINGZILIAODEZI391MINGHUANZHEMEIGEBIKONGPENLIANGCI、MEITIANLIANGCIJIYANSUANDANZHUOSITINGBIPENWUJIDE6GEDUIZHAO、2TIAN~8GEXINGQIDELINCHUANGYANJIU。ZAIANWEIJIDUIZHAOLIAOXIAOSHIYANZHONG,JIESHOUYANSUANDANZHUOSITINGBIPENWUJIDEHUANZHEYINWEIBULIANGFANYINGERTINGYAODEFASHENGLVYURONGJIANWEIJIZUMEIYOUMINGXIANDECHABIE(FENBIEWEI2.2%HE2.8%)

ZAIZHEIXIELINCHUANGYANJIUZHONG, YANSUANDANZHUOSITINGZHILIAOZUHUANZHEBIRONGJIANWEIJIZUHUANZHEGENGYIFASHENGDEBULIANGFANYINGBAOKUOKUWEI(19.7%BI0.6%)、SHISHUI(11.5%BI5.4%)、TIZHONGZENGJIA(2.0%BI0%)HEJITONG(1.5%BI0%)。

ZAIDUANQI(≤2TIAN)HEZHANGQI(2~8ZHOU)LINCHUANGSHIYANZHONG,YANSUANDANZHUOSITINGBIPENWUJIZHILIAOZUFASHENGLV≥2%HEBIANWEIJIZUGENGYIFASHENGDEBULIANGFANYINGJIANXIABIAO:

极速11选5ZAI3GEANWEIJIDUIZHAOYANJIUZHONG,GONGYOU176MING5~12SUIDEHUANZHEMEIGEPENKONGPEN1CI、MEITIANLIANGCIJIYANSUANDANZHUOSITING。ZAIZHEIXIEYANJIUZHONG,YONGYANSUANDANZHUOSITINGBIPENWUJIBIANWEIJIZHILIAOZHEGENGYIFASHENGDE、BINGQIEZAISHANGMIANCHENGRENDEBULIANGFANYINGBIAOZHONGMEIYOUTICHUDEBULIANGFANYINGBAOKUOBIYAN/GANMAOZHENGZHUANG(17.0%BI9.5%)、KESOU(11.4%BI8.3%)、JIEMOYAN(5.1%BI1.8%)HEXIAOCHUAN(4.5%BI4.1%)。

ZAIMEIGUOLINCHUANGSHIYANZHONG,YONGYANSUANDANZHUOSITING(MEIGEBIKONGPEN2CI、MEITIANLIANGCI)ZHILIAODEHUANZHEHENSHAOFASHENG(<2%HECHAOGUOANWEIJIZUDEFASHENGLV)DEBULIANGSHIJIANRUXIA:

XINXUEGUANXITONG:LIANHONG、GAOXUEYA、XINDONGGUOSU。

PIFU:JIECHUXINGPIYAN、SHIZHEN、MAONANGGANRAN、JIEBING。

极速11选5XIAOHUAXITONG:BIANMI、CHANGWEIYAN、SHEYAN、KUIYANGXINGKOUQIANGYAN、OUTU、ALTZENGJIA、KOUCHUANGXINGKOUYAN。

DAIXIEHEYINGYANG:SHIYUZENGJIA。

极速11选5JIROUGUGEXITONG:JITONG、NIEXIAHETUOJIU。

SHENJINGXITONG:JINGLUAN、GANJUECHIDUN、XUANYUN。

JINGSHEN:YOULV、RENGEJIETI、JUSANG、SHENJINGGUOMIN、SHUIMIANZHANGAI、SIXIANGFANCHANG。

HUXIXITONG:ZHIQIGUANJINGLUAN、KESOU、YANHOUZHUORE、HOUYAN。

极速11选5TESHUGANJUE:JIEMOYAN、YANJINGJIXING、YANJINGTENGTONG、LIULEI、WEIJUESANGSHI。

MINIAOSHENGZHIQIXITONG:DANBAINIAO、TINGJING、RUFANGTENGTONG、XUENIAO、NIAOPIN。

极速11选5QITA:GUOMINFANYING、BEIBUTENGTONG、DANCHUNPAOZHEN、BINGDUGANRAN、SHENTIBUSHI、SIZHITENGTONG、FUTONG。

【禁忌】

DUIYANSUANDANZHUOSITINGJIQITAFULIAOGUOMINZHEJINYONG;YUNFUJIBURUQIFUNVJINYONG;6SUIYIXIAERTONGJINYONG。

【注意事项】

极速11选51. QINGJIANGBENPINFANGZAIERTONGBUYICHUJIDEDIFANG。

极速11选52. ZAIDAKAIBAOZHUANGHOU6GEYUENEISHIYONG。

极速11选53. BENPINWEIKANGZUANYAOWU,YONGYAOHOURUCHUXIANSHISHUIZHENGZHUANG,ZEBUKEJIASHIHUODONGYONGJIXIE。

【孕妇和哺乳期妇女用药】

极速11选5RENSHENQIYONGYAODUITAIERWEIXIANCLEI:YANJIUBIAOMINGYANSUANDANZHUOSITINGKEYINQIFAYUDUXING。DUIHUAIYUNDEFUNVMEIYOUJINXINGZUGOUDEHEKONGZHILIANGHAODELINCHUANGYANJIU。ZAIHUAIYUNQIJIANZHIYOUDANGQIANZAIDEYICHUDAYUDUITAIERQIANZAIDEWEIXIANSHICAIYINGGAISHIYONGYANSUANDANZHUOSITINGBIPENWUJI。

BURUQIFUNV:YANSUANDANZHUOSITINGSHIFOUZAIRENRUZHONGFENMISHANGBUQINGCHU。YINWEIXUDUOYAOWUZAIRENRUZHONGFENMI,DANGBURUQIFUNVSHIYONGYANSUANDANZHUOSITINGSHIYINGGAITICHUJINGGAO。

【儿童用药】

GENJUGUOWAIWENXIANBAODAO,5~11SUIDEJIJIEXINGGUOMINXINGBIYANZONGHEZHENGHUANZHEMEIGEBIKONGPEN1CI、MEITIANLIANGCIJIYANSUANDANZHUOSITINGANQUANYOUXIAO。ZAIDUI176GE5~12SUIDEHUANZHEJINXING6GEXINGQIDEDUIZHAOYANJIUZHONGQUEDINGLEYANSUANDANZHUOSITINGBIPENWUJIDEANQUANJILIANGFANWEI。GENJUCHENGRENLIAOXIAOJIEGUODETUIDUAN,ERTONGYUCHENGRENZAIJIBINGJINZHANDEKENENGXING、BINGLISHENGLIXUEHEDUIZHILIAODEFANYINGXIANGSI,YIJIDUI5~12SUIHUANZHEMEIGEBIKONGPEN1CI、MEITIANLIANGCIJIYANSUANDANZHUOSITINGDELINCHUANGSHIYANZILIAOQUEDINGQILIAOXIAO。YANSUANDANZHUOSITINGBIPENWUJIDUI5SUIYIXIAHUANZHEDEANQUANXINGHEYOUXIAOXINGHAIMEIYOUQUEDING。

【老年用药】

极速11选5YANSUANDANZHUOSITINGBIPENWUJIDELINCHUANGYANJIUZHONGMEIYOUBAOKUOZUGOUSHULIANG65SUIYISHANGDESHOUSHIZHE,YINCIBUNENGQUEDINGSHIFOUTAMENDEFANYINGYUNIANQINGDESHOUSHIZHEBUTONG。QITABAODAODELINCHUANGSHIYANYEMEIYOUQUEDINGNIANLAOHUANZHEHENIANQINGHUANZHEFANYINGDECHABIE。YIBANERYAN,NIANLAOHUANZHEDEJILIANGXUANZEYINGGAIXIAOXIN,TONGCHANGCONGDIJILIANGKAISHI。

【药物相互作用】

极速11选5DANGBENPINYUJIUJINGHUOQITAZHONGSHUSHENJINGXITONGYIZHIYAOWUTONGSHISHIYONGSHIKENENGDAOZHIJINGTIXINGXIAJIANGHEZHONGSHUSHENJINGXITONGGONGNENGSUNSHANG,SUOYIYINGBIMIANTONGSHISHIYONG。

西咪替丁(400 mg每日2次)可使口服盐酸氮卓斯汀(4 mg每日2次)的 Cmax和AUC平均增加大约65%。盐酸雷尼替丁(150 mg每日2次)对氮卓斯汀的药物动力学无影响。

同时口服盐酸氮卓斯汀和红霉素或酮康唑进行药物相互作用研究,通过测量QT间期评价其对心脏的影响。口服红霉素(500 mg,每日3次,共7天)对氮卓斯汀药物动力学或QTC无影响。酮康唑(200 mg,每日2次,共7天)则影响了氮卓斯汀血浆浓度的测量,但是对QTC无影响。

TONGSHIKOUFU4mgYANSUANDANZHUOSITINGMEIRI2CIHE300 mgHUO400 mgCHAJIANMEIRI2CIWEIGUANCHADAOMINGXIANYAOWUDONGLIXUEXIANGHUZUOYONG。

【药物过量】

BENPINJINZAIBIQIANGZHONGSHIYONG,YOUYUCIYAOSUOHANYOUXIAOWUZHIJILIANGXISHAO,SUOYIJISHIDAJILIANGSHIYONG,YEBUHUIDAOZHIZHONGDUXIANXIANG。DANRUGUODAJILIANGDEWUTUNSHILECIYAO,(BIRUPINGLIDEYAOJIBEIHAIZITUNFU),QINGZIXUNYISHENG。

DONGWUSHIYANBIAOMING,ZAISHIYONGZHONGDUJILIANGQINGKUANGXIAHUICHANSHENGZHONGSHUSHENJINGWENLUANXIANXIANG(LIRU:JIAOZAOBUAN,FENNUHUOMINGXIANBIAOXIANCHUPILAOHUOKUNJUAN),YINCIBIXUGENJUZHENGZHUANGJINXINGZHILIAO。

YANSUANDANZHUOSITINGYAOWUGUOLIANGSHANGMEIYOUBAODAO。YINWEIYIPINGYANSUANDANZHUOSITINGBIPENWUJIZHIHANYOU17mgDEYANSUANDANZHUOSITING,GUCHENGRENSHIYONGBENPINJIXINGGUOLIANGCHULESHISHUIZHIWAI,BUTAIKENENGDAOZHILINCHUANGMINGXIANDEBULIANGFANYING。CHENGRENDANJILIANGKOUFUYANSUANDANZHUOSITING(ZHIDAO16 mg)DELINCHUANGYANJIUHAIMEIYOUDAOZHIYANZHONGBULIANGFANYINGDEFASHENGLVZENGJIA。RUGUOFASHENGYAOWUGUOLIANGYINGGAISHIYONGYIBANDEFUZHUCUOSHI。YANSUANDANZHUOSITINGDEJIEDUJISHANGBUQINGCHU。YINGERKOUFUKANGZUANJIKENENGYINQIYANZHONGDEBULIANGFANYING。YINCI,BENPINYINGGAIFANGZHIZAIERTONGCHUJIBUDAODEDIFANG。XIAOSHUKOUFUBENPIN120 mg/ kgHEGENGDAJILIANG(YImg/m2JISUAN,DAYUEWEICHENGRENHEERTONGMEIRIZUIDATUIJIANBINEIJILIANGDE460BEI)SHIZHIMINGDE。GOUDANJILIANGKOUFUYANSUANDANZHUOSITING10 mg/ kg(YImg/m2JISUAN,DAYUEWEICHENGRENHEERTONGMEIRIZUIDATUIJIANBINEIJILIANGDE260BEI)YOUZHELIANGHAODENAISHOUXING,DANSHIDANJILIANGKOUFU20 mg/ kgSHIZHIMINGDE

【药理毒理】

YAOLIZUOYONG

极速11选5YANSUANDANZHUOSITINGJIQIZHUYAODAIXIECHANWUSHIZUANH1SHOUTIJIEKANGJI,JUYOUKANGZUANZUOYONG。

DULIYANJIU

YICHUANDUXING:

AmesSHIYAN、DNASUNSHANGXIUFUSHIYAN、XIAOSHULINBAXIBAOZHENGXIANGTUBIANSHIYAN、XIAOSHUWEIHESHIYANJIDASHUGUSUIRANSETIJIBIANSHIYANJUNWEIFAXIANYICHUANDUXING。

SHENGZHIDUXING:

极速11选5DASHUKOUFUYANSUANDANZHUOSITING30 mg/ kg/TIANDUICIXIONGDASHUDESHENGYULIWEIJIANYINGXIANG。KOUFU68.6 mg/ kg/TIANSHI,DASHUDEDONGQINGZHOUQIYANZHANG,JIAOPEIHUODONGJIHUAIYUNSHULIANGJIANSHAO,HUANGTISHUJIPEITAIZHIRUSHUJIANGDI,DANQIZHECHUANGQIANDIUSHIBINGBUZENGJIA。

极速11选5XIAOSHUKOUFU68.6 mg/ kg/TIAN,XIANSHIYOUPEITAIDUXING、TAIZIDUXINGHEZHIJIXING(WAIGUANJIGUGEYICHANG)。DASHUKOUFU30 mg/ kg/TIAN,FAXIANGUHUAYANCHI(ZHANGGUWEIFAYU),DI14LEIGUDEFASHENGLVZENGJIA。DASHUKOUFU68.6 mg/ kg/TIAN,ZAOCHENGLIUCHANHETAIZIDUXING。ZHEIXIEZAIGAOBAOLULIANGXIAGUANCHADAODEGUGEYICHANGYURENLEIDEXIANGGUANXINGSHANGBUQINGCHU。

ZHIAIXING:

DASHUHEXIAOSHUKOUFUYANSUANDANZHUOSITING30 mg/ kg/TIANHE25mg/ kg/TIAN(ANTIBIAOMIANJIJISUAN,FENBIEWEILINCHUANGCHENGRENHEERTONGJINGBIJIYAOZUIDATUIJIANLIANGDE240HE100BEI),LIANXU24GEYUE,WEIFAXIANZHIAIXING。

【药代动力学】

GENJUWENXIANBAODAO,BINEISHIYONGHOU,YANSUANDANZHUOSITINGDESHENGWULIYONGDUDAYUEWEI40%。ZAI2~3XIAOSHINEIDADAOZUIDAXUEJIANGNONGDU(Cmax)。JINGMAIZHUSHEHEKOUFUHOUDEQINGCHUBANSHUAIQI、WENTAIFENBURONGJIHEXUEJIANGQINGCHULVFENBIEWEI22XIAOSHI、14.5L/ kgHE0.5L/h/ kg。KOUFUHOUDAYUE75%FANGSHEBIAOJIDEYANSUANDANZHUOSITINGJINGFENBIANPAIXIE,YIYUANXINGPAICHUDESHAOYU10%。TONGGUOXIBAOSESUP450MEIXITONG,DANZHUOSITINGBEIYANGHUADAIXIEWEIZHUYAOHUOXINGDAIXIEWU,QUJIAJIDANZHUOSITING。DANJILIANGBINEISHIYONGYANSUANDANZHUOSITINGHOU,WEICEDAOZHUYAOHUOXINGDAIXIEWUQUJIAJIDANZHUOSITING(FENXIXIANYIXIA)。BINEIJIYANSUANDANZHUOSITINGDAWENTAIHOU,QUJIAJIDANZHUOSITINGDEXUEJIANGNONGDUWEIDANZHUOSITINGNONGDUDE20~50%。DANGKOUFUYANSUANDANZHUOSITINGSHI,QUJIAJIDANZHUOSITINGDEQINGCHUBANSHUAIQIWEI54XIAOSHI。YOUXIANDESHUJUBIAOMINGYANSUANDANZHUOSITINGKOUFUHEBINEIJIYAODEDAIXIEQINGKUANGXIANGSI。

极速11选5RENTIXUEJIANGTIWAIYANJIUBIAOMINGDANZHUOSITINGHEQUJIAJIDANZHUOSITINGDEXUEJIANGDANBAIJIEHELVFENBIEYUEWEI88%HE97%。

盐酸氮卓斯汀每日2次,每次每只鼻孔喷2次以上共29天的研究结果表明氮卓斯汀的Cmax极速11选5和曲线下面积(AUC)增加的比例更大。

【贮藏】

MIBI,YINLIANGCHU(BUCHAOGUO20℃)BAOCUN。

【包装】

极速11选5KOUFUYETIYAOYONGGAOMIDUJUYIXIPING、YAOYONGPENWUJIDINGLIANGBENG,10ml/PING/HE。

【有效期】

ZANDING24GEYUE。

【执行标准】

ZHONGGUOYAODIAN2015NIANBANERBU

【批准文号】

GUOYAOZHUNZIH20050942

【生产企业】

QIYEMINGCHENG:SHANGHAIHENGRUIYIYAOYOUXIANGONGSI

SHENGCHANDIZHI:SHANGHAISHIMINXINGQUJINGJIJISHUKAIFAQUWENJINGLU279HAO

YOUZHENGBIANMA:200245

极速11选5DIANHUAHAOMA:021-54759103

CHUANZHENHAOMA:021-54759103

WANG ZHI:http://blumblum.com



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